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An attention-grabbing discussion is price comment. I feel that it's best to write extra on this topic, it won't be a taboo subject but typically people are not enough to talk on such topics. To the next. Cheers
Conserved signaling pathways that activate the mitogen-activated protein kinases (MAPKs) are involved in relaying extracellular stimulations to intracellular responses. The MAPKs coordinately regulate cell proliferation, differentiation, motility, and survival, which are functions also known to be mediated by members of a growing family of MAPK-activated protein kinases (MKs; formerly known as MAPKAP kinases). The MKs are related serine/threonine kinases that respond to mitogenic and stress stimuli through proline-directed phosphorylation and activation of the kinase domain by extracellular signal-regulated kinases 1 and 2 and p38 MAPKs. There are currently 11 vertebrate MKs in five subfamilies based on primary sequence homology: the ribosomal S6 kinases, the mitogen- and stress-activated kinases, the MAPK-interacting kinases, MAPK-activated protein kinases 2 and 3, and MK5. In the last 5 years, several MK substrates have been identified, which has helped tremendously to identify the biological role of the members of this family. Together with data from the study of MK-knockout mice, the identities of the MK substrates indicate that they play important roles in diverse biological processes, including mRNA translation, cell proliferation and survival, and the nuclear genomic response to mitogens and cellular stresses. In this article, we review the existing data on the MKs and discuss their physiological functions based on recent discoveries.
Cells recognize and respond to extracellular stimuli by engaging specific intracellular programs, such as the signaling cascade that leads to activation of the mitogen-activated protein kinases (MAPKs). All eukaryotic cells possess multiple MAPK pathways, which coordinately regulate diverse cellular activities running the gamut from gene expression, mitosis, and metabolism to motility, survival and apoptosis, and differentiation. To date, five distinct groups of MAPKs have been characterized in mammals: extracellular signal-regulated kinases (ERKs) 1 and 2 (ERK1/2), c-Jun amino-terminal kinases (JNKs) 1, 2, and 3, p38 isoforms ¦?, ¦?, ¦?, and¦? , ERKs 3 and 4, and ERK5 (reviewed in references 25 and 103). Since Saccharomyces cerevisiae possesses six different MAPKs, the relative complexity of the human genome suggests that there are probably several additional vertebrate MAPK subfamilies (118). The most extensively studied groups of vertebrate MAPKs to date are the ERK1/2, JNKs, and p38 kinases.
MAPKs can be activated by a wide variety of different stimuli, but in general, ERK1 and ERK2 are preferentially activated in response to growth factors and phorbol esters, while the JNK and p38 kinases are more responsive to stress stimuli ranging from osmotic shock and ionizing radiation to cytokine stimulation (reviewed in reference 147) (Fig. 1). Although each MAPK has unique characteristics, a number of features are shared by the MAPK pathways studied to date. Each family of MAPKs is composed of a set of three evolutionarily conserved, sequentially acting kinases: a MAPK, a MAPK kinase (MAPKK), and a MAPKK kinase (MAPKKK). The MAPKKKs, which are serine/threonine kinases, are often activated through phosphorylation and/or as a result of their interaction with a small GTP-binding protein of the Ras/Rho family in response to extracellular stimuli (36, 98). MAPKKK activation leads to the phosphorylation and activation of a MAPKK, which then stimulates MAPK activity through dual phosphorylation on threonine and tyrosine residues located in the activation loop of kinase subdomain VIII. Once activated, MAPKs phosphorylate target substrates on serine or threonine residues followed by a proline; however, substrate selectivity is often conferred by specific interaction motifs located on physiological substrates. Furthermore, MAPK cascade specificity is also mediated through interaction with scaffolding proteins which organize pathways in specific modules through simultaneous binding of several components.
After taking a month break next week I have to back to work. I've had a little travel with my family in the past month, and believe it or not, I never thought i could be so happy.
We travelled to Asia, spent 1 week in Japan, 2 weeks in China and few days in Korea and Thailand.
The first thing I want to mention is, trust me, original Chinese food is much delicious than those who served in China Town. They are much much much more delicious! I ate so many different food in that week, so awesome!
As to Japan, well, the most special thing in my opinion it's their video games, so many video game stores out there and you can see people play games on their cell phone, psp and Nintendo game box. Besides, I went to 2 cosplay competition in Tokyo, and I have to say it's really an eye opener for me. BTW, who said Japanese girls are easy to bang? Totally bush*t!
Korea, I like it, but I've to say their food is not very good for my family, either too spicy or little, and SO EXPENSIVE!!!
We went to Thailand last week, well, it's a mysterious country I've to say, so many amazing things I've never heard, and their spas, I never know there are so many kinds of different spas in the world, if you go their, don't miss them.
OK, this is my vocation, I just want to share it with you guys before I back to work, and hope someone would share his/her vocation with us. Best wishes!